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Phenolic Compounds In Cocoa Bean Shells Can Suppress Obesity Issues In Mice

Researchers at the University of Illinois have proposed that three phenolic compounds generally found in cocoa bean shells have influential effects on the adipose and immune cells in mice. The effects can lead to a potential setback for chronic inflammation and insulin resistance linked to obesity.

The researchers found three valuable bioactive compounds—epicatechin, protocatechuic acid, and procyanidin B2—that are present in cocoa, green tea, and coffee. Through in-vitro testing, the researchers found that these compounds play an important role in repairing the damaged mitochondria within the cells that generate energy by breaking down the fat and glucose. Therefore, the chances of accumulation of fats and glucose decrease significantly.

On a similar note, a team of researchers at Texas Biomedical Research Institute has identified a new mutation in the gene that regulates leptin, a hunger-suppressing hormone in the body. Through this discovery, the researchers could understand the actual cause behind the accumulation of excess fat. In addition to this, the study outcomes help in declining the rate of metabolic disorders such as diabetes and cardiovascular issues, which are directly associated with obesity.

In earlier research conducted in 2000, scientists at Rockefeller University analyzed rats in a laboratory that randomly gained extreme fat. The analytical results revealed that leptin hormone was not present in those rats. Humans also require sufficient levels of leptin circulating inside the body to give signals to the brain that the amount of fat in the body is enough. Eventually, the brain commands the body to stop eating.

The team of Texas Biomed examined the case associated with leptin deficiency. They studied the genetics of two sisters in Columbia, who rapidly acquired severe obesity in their childhood stage. After analyzing the sisters in their 20s at the genetic level, the researchers found that they have a mutation in their gene that was responsible for controlling leptin hormone. The levels of leptin protein were extremely low in both the sisters.

Stephanie Johnston
Stephanie Johnston Subscriber
EDITOR-IN-CHIEF At Daily Industry Updates

Stephanie Johnston is one of the highly experienced employees among the staff at the Daily Industry Updates news portal. She is dedicated to write and edit health-related articles. She has acquired the Master’s Degree in Nutrition and Dietetics, and after that preferred to pursue her career in medical writing. She also manages to write motivational medical blogs to make readers aware of their health. In this gadget-surrounded world, she enjoys outdoor activities such as cycling and jogging. She is diet conscious, holds a supplementary qualification as nutritionist and dietician and promotes health consciousness among others by writing her own blogs related to health and fitness.

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